Tuberculosis treatment

National Tuberculosis Management Guidelines 2014

Published by: 
Department of Health (South Africa)
These guidelines are meant to provide guidance to professional health care workers on the management of people with Tuberculosis as well as those co-infected with HIV. The main changes in these guidelines include;
  • Targeted screening intervention to increase detection
  • The use of Xpert MTB RIF in diagnosing pulmonary and extra pulmonary TB
  • The revised definitions and treatment regimen for retreatment patients
  • Management of adverse drug events
  • ART initiation and follow-up of patients on both ART and TB medicines
The development of these guidelines has been collaboration between the National, Provincial Department of Health and technical partners.

2013 Report on Tuberculosis Research Funding Trends, 2005–2012

Published by: 
TAC

Over the last eight years, Treatment Action Group (TAG) has tracked annual spending on tuberculosis research and development (TB R&D) and compared investments in six areas of research with the corresponding annual funding targets called for by the Stop TB Partnership’s 2011–2015 Global Plan to Stop TB (2011–2015 Global Plan). For the first seven years, TAG observed slow and unsteady increases in funding signaling slow progress toward the new tools needed to end the global TB epidemic. This year, for the first time, TB R&D investors reported a drop in spending that threatens to undermine the tenuous gains made since 2005.

The Roadmap for Childhood TB: Toward Zero Deaths

Published by: 
World Health Organization

The urgency of the problem of TB in children, whose full scope is still not fully known, cannot be underestimated. World Health Organization (WHO) estimates in 2012 revealed that up to 74 000 children die from TB each year and children account for around half a million new cases annually. It should be noted that the estimated deaths only include those in human immunodeficiency virus (HIV)-negative children. In fact, the actual burden of TB in children is likely higher, especially given the challenge in diagnosing childhood TB. Compounding this difficulty with diagnosis is the fact that children with TB often come from families that are poor, lack knowledge about the disease and live in communities with limited access to health services.

An Assessment of Current Support Strategies for Patients with TB in KwaZulu-Natal

Published by: 
Health Systems Trust

Poverty has long been recognized as one of the factors predisposing people to TB (Lancet 2005) and, in South Africa, many patients with TB live in poor conditions. In order to ameliorate these conditions, a few initiatives to support patients with TB have been made in KwaZulu-Natal. To date, support for TB patients has been provided in the form of free treatment at government hospitals and clinics (Department of Health 2001), and nutritional supplementation and social grants (Department of Social Development 2006)1.

The implementation of the National Tuberculosis Control Programme (NTCP) at a regional/district hospital and three of its feeder clinics: A Case Study

Published by: 
Health Systems Trust

The purpose of this study was to identify and understand the health system constraints to providing effective care to patients with tuberculosis (TB) in a combined regional/district hospital and three of its feeder clinics in an area with a high incidence of TB and high prevalence of HIV. The study was funded by the National Department of Health.

Rapid appraisal of primary level health care services for HIV-positive children at public sector clinics in South Africa

Published by: 
Health Systems Trust
Several effective health and social interventions are available which have been shown to improve life expectancy and quality of life in HIV-infected children. The Children's Institute (UCT) recently completed a rapid appraisal of primary level health care services to determine the extent to which some of these interventions are available to children. The study highlights the need for improved monitoring and evaluation of the implementation of existing policies and guidelines and for training of primary level health care staff on the appropriate management of HIV in children.

Tuberculosis Control Program: Implementing Proficiency Testing for TB Smear Microscopy in the Northern Province, South Africa - Guidelines for Provincial or Regional Settings

Published by: 
Health Systems Trust
The main aim of this health systems research was to assess and improve the quality of TB smear microscopy results in a systematic way in the NP, as both false positive or negative results have serious implications. This research was also initiated to pilot the logistics of the proposed proficiency testing initiative for SADC countries (including SA) on behalf of the SATCI Laboratory Task Team (in consultation with the NTCP) in order to identify operational problems and solve them. The Northern Province was chosen as the operational realities approximate that of other SADC countries.